Combination of Advagraf and CellCept led to less organ rejection; study

Keywords: Advargraf, CellCept, Astellas, Rochem Organ rejection, Kidney transplant

Combination of Advagraf and CellCept led to less organ rejection; study

Article | 31 July 2011

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For the thousands of patients who receive kidney transplants in the USA each year, preventing organ rejection without compromising other aspects of health requires a delicate balance of medications. Immunosuppresive drugs that protect transplanted organs can also cause serious side effects, including compromising patients' immunity to infection, cancer, and other threats. Finding the best combination and dosage of drugs has often proved difficult for physicians.

A new multi-year study has now shown that using tacrolimus (TAC; Japanese drugmaker Astellas’ Advagraf) and mycophenolate mofetil (MMF; Swiss major Roche’s CellCept) in combination provided the best long-term benefits and the least amount of side effects after a kidney transplant. Enjoying this article? To continue reading you need to login or subscribe .

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Combination of Advagraf and CellCept led to less organ rejection; study

Immunosuppresive drugs that protect transplanted organs can also cause serious side effects, including compromising patients' immunity to infection, cancer, and other threats. Finding the best combination and dosage of drugs has often proved difficult



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And finally, we also are facing the effect of losing current protection on CellCept. So, the combination of those effects is suddenly having a negative impact on our top line even though several of our products like Herceptin, Hepsera and very




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